A hydrogel dressing uses body heat to heal wounds

Cutbacks and abrasions are our daily bread, so virtually all of us have some dressings in the home medicine cabinet. Now it turns out that soon such sales will accelerate the healing process.

It can not be concealed, that with a few exceptions, but most dressings only serve to cover the wound and protect it from external factors, not its healing. Soon, this can change, all because of new body-activated body bandages that imitate embryonic skin. Because, as it turns out, to some point in their development, embryos do not remain scars after cuts – all because the skin cells located in the wound area produce protein fibers known as actin, pulling the edges of the wound to each other without creating a scar.

Researchers at McGill University in Montreal and Harvard University decided to use this to create a hydrogel AAD patch with the addition of silver nanoparticles and a thermoresponsive polymer called PNIPAm, which not only repels water, but shrinks at a temperature of around 32 ° C. When the dressing is applied to the skin, it begins to closely bind to it, and the skin temperature activates the polymer, leading to shrinkage of the gel and thus the connection of the edge of the wound. Moreover, most of the bacteria are minted by silver particles, so the wound has ideal conditions for healing.

In addition, the amount of PNIPAm in the hydrogel can be modified to better adapt the dressing to the place where it is applied – otherwise the skin behaves even on the elbows or knees, which needs more flexibility and mobility during work, as opposed to flat fragments. Animal tests have shown that ADD adheres to pig skin 10 times more heavily than popular dressing patches, and its use has also reduced the wound area in mice by about 45%. Not without significance is the fact that it performs better than other hydrogels tested, and additionally does not cause inflammation or other reaction from the immune system.

According to the researchers: – We are continuing our work on these studies, because we would like to learn more about the impact of our bandage on the biological process of wound healing, and how it behaves at different temperatures, because the body temperature can vary depending on the place life. We also hope for pre-clinical tests to demonstrate the potential of AAD as a medical product, and then lead to its commercialization.